Since the middle of the 20 th century, annual emissions from burning fossil fuels have increased every decade, from close to 11 billion tons of carbon dioxide per year in the 1960s to an estimated 36.6 billion tons in 2022 according to the Global Carbon Budget 2022.Ĭarbon cycle experts estimate that natural “sinks”-processes that remove carbon from the atmosphere-on land and in the ocean absorbed the equivalent of about half of the carbon dioxide we emitted each year in the 2011-2020 decade. Fossil fuels like coal and oil contain carbon that plants pulled out of the atmosphere through photosynthesis over many millions of years we are returning that carbon to the atmosphere in just a few hundred. NOAA image, based on Mauna Loa monthly mean data from NOAA Global Monitoring Lab.Ĭarbon dioxide concentrations are rising mostly because of the fossil fuels that people are burning for energy. ![]() In May 2023, carbon dioxide hit 424 ppm-a new record. ![]() At Mauna Loa, the highest monthly value each year occurs in May. The long-term trend of rising carbon dioxide levels is driven by human activities. The seasonal cycle of highs and lows (small peaks and valleys) is driven by Northern Hemisphere summer vegetation growth, which reduces atmospheric carbon dioxide, and winter decay, which increases it. This graph shows the station's monthly average carbon dioxide measurements since 1958 in parts per million (ppm).
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![]() ![]() And of course, we can safely say all four were not exactly sane, they all had mental problems. Interesting enough, all 4 members shared the same problem: All four once suffered from extreme tragedy. She specialized in using drugs and Bliss, and also, she was known as a master manipulator (which really suited her since her boss fight happened entirely in Rook’s mind).Īnd those are 4 members of Seed family, 4 leaders of the cult. With this new life, she joined Joseph’s family as the new Faith Seed. “ Lucky” for her, she found Joseph and quickly welcomed by his cult. Due to such life, she fell into depression state and the only thing could lighten her life up was drugs. She was treated rather terribly by her parents, including abuse and possibly rape. Originally, her real name was Rachel and just like other Seed family members, she had a tragic life. Also according to Joseph, her real name was not Faith and also, she was not the first “ Faith”. Unlike the other two, Faith Seed was Joseph’s adoptive sister. And good for him, he had other 3 siblings who often deemed as “ The Heralds”: Jacob Seed, John Seed, and Faith Seed. But how could a single man can manipulate and control an entire county? True, despite being a calm and ruthless figure, Joseph could not pull out all of this without help. And as we saw at the start of the game, Joseph already controlled most of Hope County. He rallied his followers and forced other local people to join his cult. He was like a psychopath who had no problem in killing and torturing the innocents. Questionable enough, he thought that his daughter would hinder his quest and therefore, killed her.ĭespite proclaiming himself as The Father, Joseph was an insane man. And somehow, he believed that was the moment he heard the message of God himself warning him about the doomsday and telling him to start the Eden’s Gate Project. No doubt, this struck a great pain into his mind. However, according to Joseph, they (possibly referring to the hospital staffs) handed him a “ pink bundle filled with tubes”. The only family member he had left was his infant daughter. Unfortunately for him, his wife died due to a car accident when they were travelling to visit a friend. ![]() Joseph actually had a wife and an infant daughter. God’s messenger – Joseph Seed (Source: Internet)īelieve it or not, the man called as “ The Father” once had a happy life. So first of all, who is Joseph Seed? Joseph Seed – The Father As the only person successfully escaped from the cult’s grasp, the players as the Rookie Deputy had to find a way to rescue his friends and put an end to this insanity. Unfortunately, their helicopter got struck down and eventually Joseph escaped. Soon, they arrested Joseph but did not succeed. Just when the team arrived, they realized that this cult problem was much, much more dangerous than what they imagined. To deal with this doomsday cult, a Junior Deputy (the players, also called in-game as “ Rook”) along with US Marshal Burke and Sheriff Whitehorse were sent to arrest Joseph. Gradually, they expanded their influence to almost entire land, including farmlands, radio stations, and even local police forces. This was a peaceful land until Joseph Seed (also known as The Father) and his family started the cult of Project at Eden’s Gate which warned about the doomsday of the world. In short, Far Cry 5 took place in Hope County, a fictional region of the United States. Welcome to Hope County! (Source: Internet) ![]() ![]() The boss fights in the game are repetitive as players have to contend with the same enemies multiple times, and they're not all that exciting or challenging. Unfortunately, the vast majority of enemies players encounter in Gylt are complete pushovers, and this extends to the boss fights. There are some mannequins introduced at one point (ever since 2005's Condemned: Criminal Origins, mannequins appear to be a requirement in horror games) that are threatening and actually scary at first, but Sally soon gets a weapon that renders them completely toothless. Things can get hairy when Sally gets surrounded by a bunch of monsters at once, but otherwise these items make the game so easy that players can basically ignore most of the stealth sections after they're acquired. However, Gylt is one of the easiest "survival-horror" games that we've played, and really players won't have to think too hard to solve its puzzles and will have to go out of their way to die.Īs the game progresses, Gylt equips Sally with some weaponry that she can use to pretty effectively fight off the monsters, including a fire extinguisher that freezes them and a special flashlight that can be used to outright kill them. When Sally isn't sneaking around monsters, she's solving standard survival-horror puzzles that we've seen countless times before, exploring spooky areas, collecting keys, and contending with "limited ammo," like in most survival-horror games. It's serviceable, though the stealth sequences are elevated significantly by the game's haunting musical score, which does a great job of heightening the tension. Much of Gylt's gameplay revolves around pretty basic stealth sequences, where players can throw pop cans to distract enemies, sneak up behind them for instant-kills, and generally just try to avoid being caught. Instead of fighting these monsters head on, Gylt encourages players to take the stealthy route. The monster designs in Gylt are creative and creepy, with Sally stalked by blobby fish people with upside-down heads, teleporting monsters with bird beaks, and even a massive humanoid creature whose consistently one of the most impressive sights in the entire game whenever it shows up. The game starts with Sally hanging up missing posters for Emily in the "real" world, but she is soon chased by some bullies into a twisted, Silent Hill-style version of her hometown, complete with giant eyeballs and deadly monsters. Players explore Gylt's visually-striking world as a young girl named Sally who is looking for her missing cousin Emily. All things considered, Gylt is quite easily the best-looking and most-polished title from Tequila Works to date. Gylt looks and runs great, with a smooth frame rate that's only ever undermined by the Stadia service itself if players decide to play on wi-fi instead of a wired connection. ![]() Gylt's art style, graphics, and lighting all come together to showcase one of Stadia's most visually impressive games. Gylt's art style also lends itself well to the "horror for kids" atmosphere it cultivates, using cartoonish visuals instead of realistic graphics. It still has a few good jump scares, but otherwise it's fairly tame for the genre. Gylt gives off a real Stranger Things vibe in that it is certainly a horror game, but it's not so overly scary that it would turn away kids or those who typically can't handle horror games. But as history has shown us, a video game platform needs strong exclusive games to reel in an audience. 21 out of the 22 Stadia launch games have been available on other platforms for months if not years, though there is one exclusive game available for Stadia Founder's Edition purchasers, and that is the stealth-horror game Gylt from Tequila Works. Google Stadia represents Google's attempt to break into the triple-A video game industry, giving players the option to stream blockbuster hits like Red Dead Redemption 2, Destiny 2, and Mortal Kombat 11 to basically any device that can get an Internet connection. ![]() A focus is placed on small molecules targeting miRNA biogenesis, lncRNAs, mRNAs encoding intrinsically disordered proteins (IDPs), and repeat expansion disorders. This review provides a general overview of recently developed RNA-targeting small molecules, highlighting advances in the field that continue to push towards the development of potent and selective small molecule lead therapeutics. ![]() ![]() Small molecule binding of an RNA target can modulate disease biology, thus creating avenues to further explore RNA-disease biology and potential therapeutics against RNA-associated disorders. 19 Conversely, small molecules are designed to target RNA structure instead of sequence, much like how small molecules are designed to target proteins via structure-based recognition. 19 RNase H recognizes the RNA–DNA heteroduplex and hydrolyzes the phosphodiester bonds of the RNA strand, cleaving it. ASOs, which often contain modified phosphate backbones and sugar motifs to protect against cellular degradation, either repress translation by sterically blocking ribosomal loading onto the RNA or induce degradation of the target RNA via Ribonuclease H (RNase H). 18 ASOs are single-stranded nucleotide sequences designed to complementarily base pair a target RNA's primary sequence. To date, two main therapeutic strategies have been employed to target disease-causing RNAs: antisense oligonucleotides (ASOs) and small molecules. 17 The biological consequences of these repeat expansions will be reviewed in detail below. This class of disorders is responsible for over 30 human diseases including Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), fragile X-associated tremor and ataxia syndrome (FXTAS), and myotonic dystrophies type 1 and 2 (DM1 and DM2). 7, 15, 16 Additionally, structured RNAs have been implicated in several neurological disorders, as reviewed in Bernat et al., 17 a well-known example being RNA repeat expansion/microsatellite disorders. For example, dysregulation of miRNAs, short regulatory RNAs that modulate gene expression via the RNA-induced silencing complex (RISC), 7 have been associated with, among others, cardiovascular disease, inflammatory disorders, and cancer. Predictably, disruption of RNA structure via mutation, formation of unnatural RNA structures, e.g., by insertions or expansions, or aberrant expression, leads to dysregulation of cellular processes, resulting in disease. As these topics will not be reviewed in depth here, we direct the reader to the references cited above for additional detail. 5 In the context of human biology, structured RNAs influence translational regulation, 6- 8 alternative splicing, 9, 10 and even enzymatic catalysis, 11- 14 further demonstrating their intimate involvement in maintaining healthy biology. The influence of these structures has been explored in the context of bacterial gene expression and riboswitches 4 and in viral replication and infection. The variability and complexity of RNA structures has been widely explored, leading to the appreciation that RNAs range from being largely disordered (dynamic) to adopting simple structures such as loops and bulges (secondary structure) to creating highly intricate pseudoknots, G-quadruplexes, and coaxial stacking (tertiary structure). ![]() The Central Dogma of biology, showcasing the numerous types of structured RNAs that have been identified to date. The compounds discussed in this review have proven efficacious in human cell lines, patient-derived cells, and pre-clinical animal models, with one compound currently undergoing a Phase II clinical trial and another that recently garnered FDA-approval, indicating a bright future for targeted small molecule therapeutics that affect RNA function. Additionally, we explore emerging RNA-target strategies, such as bleomycin A5 conjugates and ribonuclease targeting chimeras (RIBOTACs), that allow for the targeted degradation of RNAs with impressive potency and selectivity. This review highlights recent advances in this area, with a focus on the design of small molecule probes that selectively engage structures within disease-causing RNAs, with micromolar to nanomolar affinity. Although the bacterial ribosome has historically been the most well exploited RNA target, advances in RNA sequencing technologies and a growing understanding of RNA structure have led to an explosion of interest in the direct targeting of human pathological RNAs. The rich structural diversity of folded RNAs offers a nearly unlimited reservoir of targets for small molecules to bind, similar to small molecule occupancy of protein binding pockets, thus creating the potential to modulate human biology. Targeting RNAs with small molecules represents a new frontier in drug discovery and development. ![]() For the first time in the Touch series, you can communicate with your players during matches by using Shouts, allowing you to really get your point across.Level Up With DataLearn more about your team’s strengths and how to exploit opposition weaknesses. Graphical improvements and a redesigned display allow you to see more of the action, all the while receiving more useful information from your Assistant. Aim to finish the season unbeaten, see off an injury crisis or battle the odds and avoid relegation over the last few games of the season.Matchday MagicMatchdays are like you’ve never seen before in FM21 Touch. By accelerating your progress, you also won’t have to wait too long to watch your youngsters become elite.Challenge Mode offers an even more casual approach to proceedings with various ready-made trials and scenarios. ![]() Smashing through the seasons lets you focus your time on buying superstars and unearthing wonderkids - and there are thousands to be found. For more control and personalisation, there’s also a custom setting for you to stamp your individual style and preference.On Matchdays you can enjoy the action from the touchline or completely avoid it by choosing 'Instant Result' and skipping the highlights. ![]() Although you are trading a little depth for speed, FM21 Touch still packs the finesse and quality of Football Manager 2021.All the top leagues and nations are included from around the globe and your player recruitment is powered by the world’s biggest player database, which features more than 500,000 active real-life players.Tactical presets prime you for success and feature the most popular formations from around the world of football. ![]() We've used parts of the lyrics it spit out for the Pixelated Dreams song. The AI doesn't plan ahead - each word is generated based on the context up to that point. This process repeats word by word, line by line, until the AI has constructed an entire set of lyrics. The model makes an educated guess, choosing the word that most statistically fits with the given context. It does this by analyzing the context provided by the prompt and all the previous words it has generated. Once the AI has a prompt, it begins to predict the next most likely word. Write a song that takes these elements into account in the style of Bob Dylan". Our members include Dennis, Matt, Dean and Riccardo. In the case of "Pixelated Dreams" it was: "We're the Pixelated Poets, a whimsical folk band that generates music using artificial intelligence. The actual lyric generation begins with a "prompt". The most notable Large Language Models being Google Bard and ChatGPT. We don't need to train any large language model: the technology has is readily available nowadays. It identifies statistical patterns and uses them to predict what comes next. However, it's important to clarify that the AI doesn't "understand" the text in the way humans do. Through this process, the AI learns about grammar, rhymes, common phrases, and even thematic elements. This allows the model to learn the structures, patterns, and nuances of language. Large Language Models have been trained by ingesting enormous amounts of text data from the internet, including books, articles, and, importantly for our purposes, song lyrics. These models are powerful tools that use machine learning to generate human-like text. When you listen to a song from Pixelated Poets, you might wonder: "How does an AI write such emotionally resonant lyrics?" The answer lies in the complex machinery of Large Language Models (LLMs). You can view the music video of the AI-produced song here: How does AI compose lyrics that resonate with human experiences? How does it craft a melody that makes a song memorable? And most importantly, how does AI go beyond ones and zeros to create art that touches hearts? Join us on this magical musical adventure to uncover the answers. In this blog post, we're going to dive deep into the fascinating process behind Pixelated Poets. Every frame of these videos is a testament to the power of AI in generating compelling visual art. We've also utilized AI to produce our very own music videos, creating a rich visual narrative that harmonizes perfectly with our music. This includes the song descriptions that capture the spirit of each track, the lyrics that weave intricate narratives, the melody that paints the air with musical hues, and the rhythm section consisting of bass, backing tracks, and drums that set the groove. Instead, our band members are a complex network of algorithms, working in unison to compose music that evokes emotions, tells stories, and sets your foot tapping.Įverything you're about to explore here, from the catchy band name to the mesmerizing tunes, has been birthed by AI. ![]() There's no lead vocalist passionately belting out notes, no guitarist strumming heart-tugging melodies, and no drummer rhythmically guiding the tempo. Welcome to the incredible journey of "Pixelated Poets", a whimsical AI-driven folk band where creativity meets artificial intelligence. One such wonder is the impact AI has made on the creative world, specifically music. It's spreading its wings across diverse fields, revolutionizing industries and creating unexpected wonders. In this era of rapid technological advancement, Artificial Intelligence (AI) is no longer confined to data analytics or automated systems. So, let's dive in and hit the high notes of this exciting musical saga. It’s an expedition into the unknown, a chronicle of innovation, and most importantly, a celebration of how creativity and technology can together compose a beautiful symphony. ![]() The journey of Pixelated Poets is a testament to the endless possibilities AI brings into our lives. Pixelated Poets: How Generative AI fully fuels our music production ![]() ![]() Per the rules in most states, expect that a West Virginia driver’s license for a new resident to the state is only available to those who do not have any outstanding suspensions, revocations, or cancellations on their out of state driver’s license and who have not been previously deemed unfit or unsafe to drive by the West Virginia DMV or an outside court. To get a West Virginia driver’s license as a formerly out-of-state resident you’ll have to go to a Division of Motor Vehicles office location in person, since unfortunately you can’t do a West Virginia DMV change of address online or over the phone as a new resident. How do you get a new driver’s license in West Virginia? Yes, unless you are a student who will not be permanently moving to the state or an active member of the U.S. Will you need to get a new driver’s license if you’re moving to West Virginia from another state? If You’re Moving to West Virginia from Another State We’ve put together all of the information that you’ll need to know to complete your West Virginia DMV change of address and vehicle registration forms, so read through the information below and then make your way to your local West Virginia Division of Motor Vehicles office to get started. Not sure where you should start? That’s where we come in. And since West Virginia requires that you file your change of address paperwork within just 30 days of establishing residency in the state, there really isn’t a whole lot of time to waste. It’s good practice to take care of all of your paperwork as early as possible, especially if you’re going to be driving in the state or want to start applying for jobs. Like all states, you’ll be required to get your West Virginia DMV change of address forms in order before you can truly settle in as a resident-including your address on your driver’s license and an update to your vehicle’s registration documents, if applicable. If you’re planning on moving to, from, or within the state of West Virginia then you’re going to want to make sure that you know exactly what’s expected of you in terms of DMV paperwork. ![]() Review, revise, and develop SOP’s as requestedįollow all quality, safety, company and other laboratory protocols at all timesĬonduct basic troubleshooting, maintenance of lab equipment, and SQC as required Maintain a clean and orderly work environment including stock and inventory Pick up and deliver sample cylinders to units Use a variety of instrumentation including GC Utilize a LIMS sample to enter sample data The QC Lab Tech is responsible for running routine samples to ensure quality assurance of raw materials, in-process samples, and final products.Īccurately analyze all samples to ensure data integrityĪnalyze unit stream and feed stocks to ensure operational success *Prior experience using Chemistry and Immunoassay Analyzer such as Roche Cobas 6000, Hematology Systems like Abbott CELL-DYN Ruby, Urine Chemistry Analyzer and Microscopy is strongly preferred.Īvailable shift: 1pm to 9:30pm, rotating/on-call SaturdaysĬompany DescriptionA newly formed company from mergers establishing a productive, collaborative and strategically minded team drawing from experience and expertise to build an exceptional organization.Company DescriptionA newly formed company from mergers establishing a productive, collaborative and strategically minded team drawing from experience and expertise to build an exceptional organization.
While you may be inspired by these accounts, please note that any stories of success have not been verified and your individual path to Optimal Health may vary. ![]() The results relayed in these messages are based on the unique experiences of the participants and we cannot guarantee like or similar outcomes. During this session, Shantelle, Russ, Gina, Matt, Mary Ellen, and Deanna & David share their Ultrahealth journeys and tips on how you can start planning yours! **The following audio may contain the personal testimonies of some OPTAVIA Coaches or Clients of OPTAVIA®. Join Independent OPTAVIA Coach Shantelle Flake along with guest speakers Russ Scarce, Gina Echols, Matt Engstrom, Mary Ellen Loranger, and Deanna & David Asencio as they discuss the mindset and habits behind Ultrahealth. As always, it is our recommendation that you consult with a healthcare provider before starting a weight-loss program. growth mindset, the Hot or Go and Cool or Know Systems, and the four important questions that can help guide you through challenging situations.**The following audio may contain the personal testimonies of some OPTAVIA Coaches or Clients of OPTAVIA®. ![]() Ben discuss the difference between having a closed vs. During this session, Dawn, Crystal, Krista, and Dr. Ben Britton as they share tips and strategies on how to optimize your relationships. Forget fad diets, unused gym memberships and quick fixes, your coach and community can help make optimal health a reality.Join Independent OPTAVIA Coach Dawn Fischer along with guest speakers Crystal Cunningham and Krista & Dr. Here’s the best part: While weight loss may be a benefit of joining OPTAVIA, the main goal is to focus on what’s added to your life rather than what’s subtracted from the scale. There are also clinically proven plans, which include scientifically developed products called Fuelings and simple healthy recipes called Lean & Green meals, to help jumpstart your weight loss journey while you work on building those healthy habits that will serve you in the long-run. Think of microHabits as small choices you make on a daily basis rather than making one large sweeping change at once (spoiler alert: this makes them easier to stick with). In addition to the coaches and community, the Habits of Health system will help you adopt new healthy habits, or microHabits as they’re referred to in the program, in six key areas: weight management, eating and hydration, mind, surroundings, motion and sleep. Need even more reinforcement? You’ll also be connected to a community of thousands of other people who are all on a similar journey and there to provide inspiration whenever needed. ![]() The health benefits of social interaction have been studied time and time again, including studies showing the impact support can have on weight management when combined with a supervised program. In a 2019 study published in the journal of Obesity Science and Practice, they found that the structured program, which included one-on-one coach support, was more effective than a self-directed, reduced-calorie diet alone for weight loss. It’s this part of the program that’s more than just a nice-to-have. And there’s no one better suited since about 90 percent of OPTAVIA coaches were clients first, so they’re more than familiar with the path you’re on and can help steer you towards success. They empower and encourage you in real-time as you move along in your journey. That’s why OPTAVIA coaches are the lifeblood of the program, and there’s a community of thousands of them. adults believe they would be more successful in creating healthy habits if they had support from someone who has been in their shoes. What’s their role exactly?Īccording to a recent survey, 81 percent of U.S.
![]() ![]() This means that users can get official access to new apps before they are available on the official Play Store. The main reason is that new apps have been leaked in advance and are available for download as APK files. APK files are popular for many reasons.What are the Pros and Cons of installing the Forbidden Passion apk file on your Android phone? Pros: A prompt will appear and you can check to see if there are any hidden files. Click once on the "More" link in the upper right corner. Q4 How to find hidden apk files on an Android phone?Īns: To view hidden files on your child's Android device, go to the My Documents folder, then go to the storage folder that you can check - either device storage or SD card. Where can I find apk files on Android?Īns: If you want to find apk files on your Android phone, you can find apk in the/data/application/directory under user-installed application, whereas pre-installed files are in the system/application folder using eS. One can modify the APK maliciously before installing it and then use it as a digital Trojan horse to install and operate the mover Therefore, you need to make sure that the website you are using,, is trustworthy. Is it safe to download the Forbidden Passion Apk file from ?Īns: APK files install applications on your system so that they pose a serious security risk. If you want to install an APK, you need to manually download and run the file (a process "sideloading"). Frequently Asked Questions(FAQ)Īns: The APK extension is used for the Android package kit and the file format is used to install the Android application (X. Then tap on the button to run it, this option is available in the security settings of your Android mobile phone. There you will have to wait for some time to load the content. Then install and launch it on your phone. You can go to "Download" in your browser and tap once on the downloaded file. Open the menu, settings, and security, and search for unknown sources so that your phone can install applications from sources other than Google Play Store, and. To make this possible, the following steps are largely the same. A confirmation window will pop up based on your browser preferences. Which can be found anywhere on the Internet before you can install it on your phone, you need to make sure that third-party applications are allowed on your device. After downloading, you find APK on your browser's "Downloads" page. To start the download, you can download Forbidden Passion by clicking the button above. The best collection of movies and shows. ![]() Added voice acting to Premium Content (More in the SubscribeStar version).Over +1000 renders, 3200 unique renders overall.~9 fully realized animations made of about 400-500 renders.Will he succumb to his condition and bad situation or will he rise up to the challenge? The choice is yours and yours alone. 0.9 Standard “Ok.am sorry…how about we fix a date to meet.Forbidden Passion is about the story of a young man who’s been kicked out of his house and now has to manage this chaotic life, while having to take care of the woman and people he loves the most. ”…”you don’t need to tell me…I already know she doesn’t,as I and sophie walked straight to class …we both saw Alvin standing in front of us…why can’t these people just stay at home.I talked to my self as sophie just vanished leaving I and this strange handsome guy… as she took her leave…I don’t get this woman…now my foot hurts so badly…I almost did something crazy but Sofia cooled me Down.”you can see she started it …”I turned to Sofia “please just ignore her…am sure she just don’t like you that’s why she’s acting all like this. how may I help you ?”I asked trying really hard to be polite as she just stepped on my shoes purposely and smiled mischievously. what does she wants again.why can’t she just stay away from me…”so madame. but not everyone seems happy for me…”Hey you !”I heard a female voice from the back while talking to sofia my friend as I turned…here she is ,the owner of vegan college daughter. Two weeks passed very soon and I was back to school.I was so very happy to be back to School again. ”well am in love with Alvin “I returned back “please don’t call his name here …,what’s in that dude that you like so much ?”victor now removed his hands from my waists staring at me angrily…”hey don’t you yell at me ok.?I only agreed to do this with you because you make me feel more like a woman…nothing else !” Veronica stood up …as Victor cuts in.”where are you off to ?”…”wanna go shower …you wanna join me or you just gonna lay there…”I said smiling seductively …that was the only way I could keep Victor wrapped in my hands…sex ! Sex is fun especially with someone like victor…victor wrapped his full arms round my waists as he gives me warm kisses on my cheeks…”I love you baby. |
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